TNF Receptor

Synonym:

Structure/Function

Two receptors of 55 kDa (TNF-R1; new designation: CD120a) and 75 kDa (TNF-R2; new designation: CD120b) have been described. One receptor is a glycosylated protein of 455 amino acids that contains an extracellular domain of 171 and a cytoplasmic domain of 221 amino acids. Sequence homologies in the cysteine-rich domains of the extracellular portion reveal that the receptor is related to the low-affinity receptor of NGF and to human cell surface antigen CD40 . Deletion analysis in the C-terminal intracellular region of the 55 kDa receptor, TNF-R1 has revealed the existence of a so-called death domain , which is involved in signaling processes leading to programmed cell death. The death domain of TNF-R1 interacts with a variety of other signaling adaptor molecules, including TRADD , and RIP .

GenBank (through Genome Net)

Sequence Information

Journal Information