Erythropoietin receptor
Synonym:
Structure/Function
The murine receptor is a protein of 507 amino acids with a single membrane-spanning domain. The
cytoplasmic domain has a length of 236 amino acids. A point mutation at codon 129 of the murine Epo
receptor gene results in constitutive activation. Mice expressing the aberrant receptor develop
erythrocytosis and splenomegaly. Clonal growth factor-independent, proerythroblast cell lines that express Epo receptor have been isolated from the spleen of these
animals.
Sequence Information